Curious Minds: UGANDAN PHARMAPEDIA

 MIYINGO Ivan, MPhil, B. Pharm, MPS.  

Curious Minds

____________________________________________________

UGANDAN PHARMAPEDIA

ACICONE-S ORAL SUSPENSION

NDA Registration Number: NDA/MAL/HDP/1607

License Holder: Medical Union Pharmaceuticals

Local Technical Representative: Karuri Pharmaceuticals Ltd.

Name of Drug: Acicone-S Oral Suspension

Generic Name of Drug: Magaldrate + Simethicone (540mg/5ml + 40mg/5ml)

Manufacturing Site: Medical Union Pharmaceutical Co., Plant: Abu-Sultan, Ismailia, Egypt

Country of Manufacture: Egypt

Dosage Form: Oral Liquid Ordinary Suspensions

Pack Size: 1.0 x 120.0 ml Bottle




Mechanism of Action

Acicone-S Oral Suspension offers quick gastrointestinal relief through complementary mechanisms. Magaldrate, a chemical complex of aluminum and magnesium hydroxides, reacts with gastric acid to neutralize it, sustaining a therapeutic pH range of 3 to 5 while reducing pepsin activity. Simethicone acts as a surfactant or antifoaming agent, lowering the surface tension of gas bubbles so they coalesce into larger, easily expelled units, relieving flatulence, bloating, and pressure.

Sediproct Cream

NDA Registration Number: NDA/MAL/HDP/1503

License Holder: Medical Union Pharmaceuticals

Local Technical Representative: Karuri Pharmaceuticals Ltd.

Name of Drug: Sediproct Cream

Generic Name of Drug: Hydrocortisone + Cinchocaine (0.5% w/w + 0.5% w/w)

Manufacturing Site: Medical Union Pharmaceutical Co., Plant: Abu-Sultan, Ismailia, Egypt

Country of Manufacture: Egypt

Dosage Form: Topical External Other Creams

Pack Size: 1.0 x 20.0 g Tube





Mechanism of Action

Sediproct cream provides rapid symptomatic relief through a dual-action mechanism. Hydrocortisone acts as a mild corticosteroid that binds to intracellular receptors, downregulating inflammatory mediators to suppress local swelling, redness, and itching. Cinchocaine functions as a potent local anesthetic, blocking voltage-gated sodium channels in sensory nerve fibers to temporarily halt the propagation of pain impulses. Together, they soothe inflamed tissue and numb localized anorectal discomfort.

INSULINAGYPT 70/30 100 IU/ML Injection 10 ML

NDA Registration Number: NDA/MAL/HDP/10119

License Holder: Medical Union Pharmaceuticals

Local Technical Representative: Karuri Pharmaceuticals Ltd.

Name of Drug: Insulinagypt 70/30 100 IU/ML Injection 10 ML

Generic Name of Drug: Insulin Human (Recombinant DNA Origin) 100 IU/ML (70% Isophane Insulin + 30% Regular Insulin)

Manufacturing Site: 6th October Site, 2nd Industrial Zone, Plot No. 1, Street No. 22, Giza Governorate, Egypt

Country of Manufacture: Egypt

Dosage Form: Parenteral Ordinary Vials

Pack Size: 1.0 x 1.0 x 10.0 ml Vial



Mechanism of Action

Insulin Human 70/30 regulates glucose metabolism by binding to specific cell receptors on muscle and fat tissues. This binding triggers GLUT4 transporter translocation, accelerating glucose uptake from the bloodstream. Simultaneously, it inhibits hepatic glucose production via gluconeogenesis and glycogenolysis. The 30% regular insulin provides a rapid onset to control postprandial glucose surges, while the 70% crystalline isophane insulin extends action to manage baseline glucose levels.

HEPATICUM - Silymarin 50mg/5ml Oral Suspension 120ml

NDA Registration Number: NDA/MAL/HDP/0212

License Holder: Medical Union Pharmaceuticals

Local Technical Representative: Karuri Pharmaceuticals Ltd.

Name of Drug: Hepaticum

Generic Name of Drug: Silymarin (1g/100ml)

Manufacturing Site: Medical Union Pharmaceuticals Ltd, Abu Sultan, Ismailia

Country of Manufacture: Egypt

Dosage Form: Oral Liquid Ordinary Suspension

Pack Size: 1.0 x 120.0 ml Bottle



Mechanism of Action

Silymarin stabilizes liver cell membranes, blocking toxins from entering. It boosts protein synthesis and cellular regeneration by stimulating RNA polymerase I, helping repair damaged liver tissue. As a potent antioxidant, it scavenges free radicals and replenishes glutathione levels, reducing oxidative stress. Additionally, it downregulates inflammatory pathways, providing hepatoprotective effects against toxins, alcohol, and metabolic stressors.

HEPATICUM - Silymarin Capsules 140mg

NDA Registration Number: NDA/MAL/HDP/0210

License Holder: Medical Union Pharmaceuticals

Local Technical Representative: Karuri Pharmaceuticals Ltd.

Name of Drug: Hepaticum

Generic Name of Drug: Silymarin (140 mg)

Manufacturing Site: Medical Union Pharmaceuticals Ltd, Abu Sultan, Ismailia

Country of Manufacture: Egypt

Dosage Form: Oral Solid Ordinary Capsules

Pack Size: 1.0 x 3.0 x 10.0 Capsule Blister



Mechanism of Action

Silymarin stabilizes liver cell membranes, blocking toxins from entering. It boosts protein synthesis and cellular regeneration by stimulating RNA polymerase I, helping repair damaged liver tissue. As a potent antioxidant, it scavenges free radicals and replenishes glutathione levels, reducing oxidative stress. Additionally, it downregulates inflammatory pathways, providing hepatoprotective effects against toxins, alcohol, and metabolic stressors.

DISPERCAM - PIROXICAM 0.5% GEL 30G

NDA Registration Number: NDA/MAL/HDP/0052

License Holder: Medical Union Pharmaceuticals

Local Technical Representative: Karuri Pharmaceuticals Ltd.

Name of Drug: Dispercam

Generic Name of Drug: Piroxicam (0.5% w/v)

Manufacturing Site: Medical Union Pharmaceuticals Ltd, Abu Sultan, Ismailia

Country of Manufacture: Egypt

Dosage Form: Topical External Gels and Solutions

Pack Size: 1.0 x 15.0 g Tube, 1.0 x 30.0 g Tube





Mechanism of Action

Piroxicam gel provides localized pain relief by penetrating the skin to inhibit cyclooxygenase (COX) enzymes. This action blocks the synthesis of prostaglandins, which are the chemical messengers responsible for triggering inflammation, swelling, and pain signals in tissues. By lowering prostaglandin levels directly at the affected site—such as a joint or muscle—it reduces localized swelling and eases movement while minimizing systemic side effects.

DEXAMETHASONE SODIUM PHOSHATE 8MG/2ML

NDA Registration Number: 7/1/08 NDA/MAL/HDP/12056

License Holder: Medical Union Pharmaceuticals

Local Technical Representative: Karuri Pharmaceuticals Ltd.

Name of Drug: Dexamethasone Sodium Phosphate

Generic Name of Drug: Dexamethasone Sodium Phosphate

Manufacturing Site: Medical Union Pharmaceuticals Ltd, Abu Sultan, Ismailia

Country of Manufacture: Egypt

Dosage Form: Parenteral Ordinary Ampoules

Pack Size: I. 1 × 100 × 2 mL Ampoule



Mechanism of Action

Dexamethasone is a potent glucocorticoid that diffuses across cell membranes to bind intracellular glucocorticoid receptors. This complex alters gene transcription, blocking pro-inflammatory cytokines (like IL-1, IL-6, TNF-alpha) and downregulating COX-2 enzymes to stop prostaglandin synthesis. It also suppresses the immune response by inhibiting T-lymphocyte activation and reducing capillary permeability, rapidly controlling severe inflammation, shock, and cerebral edema.
_______________



______________________________________

FROM: The Letters to Atiah Miyingo


© 2095





Comments

Post a Comment

Popular posts from this blog

42 LIFE LESSONS

Image
BY: MIYINGO Ivan, MPhil, B.Pharm, MPS YOU'RE DEAD IN THE YEAR 2089,  Your ancestors survived centuries of floods, slavery, and world wars, thinking of which whoever named it World War One (I) knew there was going to be a second.  They survived the Holocaust, where six million jews were exterminated in gas chambers by Adolf Balikuddembe Hitler.  They survived plagues and pandemics, and in the year 2099, you will be an ancestor who survived the COVID-19 pandemic.  For you to sit on the toilet and scroll through people’s fake lives on Instagram and Snapchat whilst comparing yourself to people you have never met is not only an insult to your ancestors, but a disturbance to the peace of the walking dead as well.  You don’t need more, you need less of what doesn’t really matter. Freedom starts when you stop needing to be liked.  As long as your thoughts and decisions are constantly filtered through by what they will say or think, then you’re in prison, and you ne...
Read more

WAR: Iran, Israel, and the United States

Image
BY: MIYINGO Ivan, MPhil, B. Pharm, MPS The conflict between Iran, Israel, and the United States did not begin as a single war overnight; it evolved through decades of ideological hostility, proxy warfare, assassinations, sanctions, covert operations, cyber warfare, nuclear disputes, and regional power struggles.  Its roots trace back to the 1979 Iranian Revolution, when the pro-Western Shah of Iran was overthrown and replaced by the Islamic Republic under Ayatollah Khomeini. Before this revolution, Iran and Israel had quiet strategic relations, and Iran was a close ally of the United States.  After the revolution, the new Iranian government adopted a fiercely anti-American and anti-Israeli posture, viewing both states as symbols of Western domination in the Middle East.  The seizure of the U.S. Embassy in Tehran and the 444-day hostage crisis transformed Iran into a permanent adversary of Washington, while Israel increasingly viewed revolutionary Iran as an existential th...
Read more

SIX BLIND MEN AND THE ELEPHANT

Image
BY: MIYINGO Ivan, MPhil, B. Pharm, MPS THE 6 BLIND MEN AND THE ELEPHANT The story of the blind men and the elephant is a famous philosophical parable about perception and truth.  In the story, several blind men encounter an elephant for the first time, but each touches only one part of the animal.  The man who touches the elephant’s side believes it is a wall because the surface feels broad and solid.  Another touches the trunk and insists it is a snake because it feels long and moving.  One who touches the tusk says it is a spear, while the one holding the leg believes it is a tree because it feels thick and sturdy.  The man touching the tail concludes it is a rope, and the one touching the ear says it is a fan because of its wide and flexible shape. Each man is partially correct, yet completely wrong about the whole elephant. The story teaches that human beings often mistake limited experience or perspective for complete truth.  People see only fragments ...
Read more